Do you believe LC/MS is still a complicated and difficult-to-handle technique? This is not the case with the UltiMate® LC/MS system. The UltiMate System Wellness technology, automatic calibration of the MS detector, and self-cleaning ion source allow for continuous routine operation without the need for frequent cleaning or maintenance. The complete system is easy to use and requires very little setup or fine-tuning to achieve optimum sensitivity. You no longer have to learn two software packages to operate your LC/MS system. Chromeleon® LC/MS software provides single-software method setup and instrument control, powerful UV and MS data analysis, and fully integrated reporting.
With Dionex Intelligent LC (LCi) solutions you can get more out of your LC/MS investment. Technologies such as tandem chromatography allow you to increase sample throughput by as much as 100%. Other advanced chromatography techniques like 2-D LC or on-line SPE-LC are also available for the UltiMate 3000 LC/MS system, allowing you to automate analyses in your laboratory like never before.
For optimal performance of microbore LC methods, the UltiMate 3000 single quadrupole MS system is based on an UltiMate 3000 RSLC System. This approach involves the following modules:
Little Space Required
Save space in your laboratory with modern compact instruments. A complete UltiMate LC/MS system is less than 80 cm (31 in.) wide, and is one of the most compact LC/MS system on the market today. The integrated design of the MSQ Plus detector has led to an approximate twofold decrease in footprint area and system volume compared to previous MS systems, with no compromise in system performance. On the contrary, design changes have been implemented that significantly increase performance and functionality.
Performance
Reliably detect trace components with the most sensitive single quadrupole LC/MS system available. The MSQ M Path™ triple orthogonal source virtually eliminates neutral noise and background, assuring extreme sensitivity from real samples. The UltiMate HPLC system ensures the stable operating conditions required for continuous high-ionization yields. Furthermore, with an UltiMate LC/MS system you do not need to reinvent the wheel. The MSQ Plus is compatible with existing LC methods, especially those including salts, ion-pairing agents, and dirty matrices, and can be operated over a wide range of conditions, including flow rates up to 2 mL/min.
Robustness and Reliability
The UltiMate LC/MS system with the MSQ Plus Mass Spectrometric Detector is extremely robust and reliable, allowing routine operation over extended periods, even in unattended mode. The self-cleaning atmospheric pressure ionization (API) source ensures continuous high sensitivity without the need for frequent cleaning, even when using inorganic buffers or ion-pairing agents. UltiMate System Wellness technology ensures that the HPLC instruments continuously perform under optimal conditions. Warnings are automatically generated if one of the HPLC modules detects a problem, thereby preventing wasted resources from unconsciously running the system under suboptimal conditions.
Maximum Flexibility
With the UltiMate LC/MS system, you have flexibility with respect to supported MS techniques and required flow conditions. The MSQ comes with atmospheric pressure ionization (API), with both electrospray ionization (ESI) and atmospheric chemical ionization (APCI) capabilities. The system can switch source polarity for the analysis of both positive and negative ions or change the cone voltage (collisional induced fragmentation) on sequential scans across a chromatographic peak. The UltiMate HPLC pump can be optimized, within minutes, for the lowest gradient delay volume and superior mixing. When operating your system at low flow rates (<200 µL/min), lowest gradient delay optimization considerably reduces your analysis times, and therefore improves the total throughput of your system. When using ion-pairing agents or poorly miscible eluents, superior mixing optimization increases the sensitivity of your system.
More Information in Less Time
As an LC/MS user, you spend a considerable amount of your time with data analysis and reporting. Chromeleon LC/MS software is the most intuitive and most powerful chromatography software package on the market, and allows you to extract more information from your data in less time. It provides fully integrated LC/MS method and instrument control, fast comparisons and extraction, background correction of mass and UV spectra, and Microsoft Excel-type reporting for data from all detectors. You spend less time learning new software, freeing more time for your analytical work.
