Chlorination of drinking water for disinfection results in the formation of haloacetic acids, several of which exhibit adverse carcinogenic effects in humans. Monochloro-, monobromo-, dichloro-, dibromo-, and trichloro-acetic acids are regulated under the U.S. EPA Stage II Disinfection By-Products Rule at a cumulative total concentration less than 60 ppb. Dionex and the U.S. EPA Office of Ground Water and Drinking Water are developing a direct injection IC-MS/MS method for the determination of the nine chloro- and bromo-haloacetic acids. This IC-MS/MS method will save sample preparation time relative to the current method, which requires derivatization before analysis. 
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