The perchlorate anion has attracted widespread attention within the environmental community over the last decade as a potentially regulated contaminant, due to concerns that it interferes with iodide uptake in the human thyroid. The U.S. EPA Office of Ground Water and Drinking Water, and Office of Solid Waste and Emergency Response have focused on develompent of robust detection methods based on ion chromatographic (IC) separations with both suppressed conductivity and mass spectrometry (MS). The U.S. FDA has been examining perchlorate occurrence in food supplies, while the Centers for Disease Control (CDC) have targeted assessment of human exposure. Robust IC, IC-MS, IC-MS/MS, and LC-MS methods are now available for measurement of perchlorate in numerous sample matrices. - Method 314.0: IC with suppressed conductivity detection and IonPac® AS16 column
- Method 314.1: IC with Cyrptand colum concentration/matrix elimination with dual column confirmation using the IonPac AS16 and AS20 columns
- Method 314.2: Two-Dimensional IC with the AS20 and AS16 IonPac columns and suppressed conductivity detection
- Method 331.0: LC-MS/MS using the IonPac AS21 column
- Method 332.0: IC-MS and IC-MS/MS with the IonPac AS16 and AS20 columns
- Method 6850: LC with MS and MS/MS detection on the AS20 column
- Method 6860: IC with MS and MS/MS detection on the AS16 and AS20 columns
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