This simple application of the Acclaim^® PA resolves all the active ingredients and most of the inactive ones in cough syrup. At pH 3, three of the active ingredients are only weakly hydrophobic and one is moderately hydrophobic. The Acclaim PA is well suited to the low-organic conditions needed for this separation. Note that the Acclaim PA delivers a sharp peak for pseudoephedrine, a hydrophilic, basic drug that is difficult for columns with high silanol activity.