OmniPac PCX-100 Cation-Exchange Column for the Separation of Low-Molecular-Weight Species

The OmniPac^® PCX-100 column is a microporous, solvent-compatible, high-capacity, cation-exchange column designed for the separation of hydrophobic cations, such as amines, drugs, and metabolites.

Acid, base, and solvent compatible, pH 0–14
Good for organic cations
Ideal for the separation of very hydrophobic cations
Good for the separation of halogenated cations

The OmniPac PCX-100 column is a specialty cation-exchange column for the separation of low-molecular-weight cations, especially organic analytes. Group 1A and 2A inorganic cations are best separated on the IonPac CS12A column, which is also solvent compatible. The OmniPac PCX-100 column is 100% solvent compatible and should always be run with at least 1% organic solvent in the mobile phase.

The OmniPac PCX-100 is manufactured using a microporous substrate agglomerated with a sulfonated latex bead layer that carries the cation-exchange functionality. The cation-exchange layer is the same as that used in the OmniPac PCX-500 column, and consequently the ion-exchange characteristics of these two columns are identical. The OmniPac PCX-100 column can be used to separate hydrophobic cationic analytes such as amines, anilines, antidepressants, drugs, and metabolites (such as methotrexate and folic acid).

OmniPac PCX-100 Cation-Exchange Column for the Separation of Low-Molecular-Weight Species Specifications
Dimensions	OmniPac PCX-100 Analytical Column: 4 × 250 mm OmniPac PCX-100 Guard Column: 4 × 50 mm
Maximum operating pressure	4000 psi (27.9 MPa)
Recommended operating temperature	Ambient
Typical operating conditions	1.0 mL/min with at least 1% organic solvent Recommended flow rate: 1.0 mL/min
Mobile phase compatibility	100% compatible with common organic solvents. Recommended eluents: 1% solvent. Acid to maintain weak bases in the cationic form, salt (e.g., Na⁺ for cation-exchange).
Resin composition	8.5-µm-diameter ethylvinylbenzene/divinylbenzene microporous substrate (55% cross-linked) agglomerated with 200-nm MicroBead^TM sulfonic acid-functionalized latex (5% cross-linked).
Anion-exchange capacity	120 µeq/column (4 × 250 mm analytical column)
Column construction	PEEK with 10-32 threaded ferrule-style end fittings. All components are nonmetallic.

Order Information
OmniPac PCX-100 Analytical Column (4 x 250 mm)	042189
OmniPac PCX-100 Guard Column (4 x 50 mm)	042193

Data Sheets
	OmniPac PCX-100 Analytical Column Manual 474K
	AN 70: Choline and Acetylcholine 381K