The Acclaim® Mixed-Mode WCX-1 is a novel, high-efficiency, silica-based column specially designed for separating various basic analytes.
This new packing material features a combination of both reversed-phase and weak cation-exchange properties by incorporating
a hydrophobic alkyl chain with carboxyl terminus.
The Acclaim Mixed-Mode WCX-1 columns feature:
- Adjustable selectivity
- Orthogonal selectivity
- Ideal for separating basic analytes – excellent peak shape, sufficient retention, high efficiency
- Multi-retention mechanisms – reversed-phase, cation-exchange, ion-exclusion, and HILIC
- Broad range of applications
The Acclaim Mixed-Mode WCX-1 unique surface characteristics facilitate adjustable selectivity. Retention times can be adjusted
by changing mobile phase ionic strength, pH, and organic solvent content, individually or concurrently.
The HPLC analysis of basic compounds is often challenging when using reversed-phase silica columns, especially hydrophilic
basic compounds. The new Acclaim Mixed-Mode WCX-1 column circumvents these difficulties. It retains basic molecules with symmetrical
peak shapes and excellent efficiency.
Many application are developed on reversed-phase C18 columns, though secondary analytical methods are often required with
orthogonal selectivity. Because of the adjustable selectivity of the Acclaim Mixed-Mode WCX-1 column, it is an ideal column
for this purpose.
